FORMULATION OPTIMIZATION AND INVITRO EVALUVATION OF NIACIN PROLONGED RELEASE TABLET
Chavala Vasanthi*, Senige Mallikarjuna Reddy, Tunga Udaykiran and Mudadla Durga Prasad
The objective of the present research work is to develop a pharmaceutically stable, cost effective and quality improved formulation of “Niacin prolonged release matrix tablets” which is to be bioequivalent with reference product. For the preparation of niacin prolonged release tablets both direct compression and wet granulation method using various polymers such as Methocel K100M, Methocel E15LV, Pharmatose 200M, Cutina HR, Pamster and aerosol. Wet granulation method was carried out in fluidized bed processor with optimized parameters. Tablets were prepared and evaluated for thickness, hardness, friability, weight variation, content uniformity, and in vitro drug release. For the entire formulations similarity factor and dissimilarity factors were calculated among all these results formulation 8 values are satisfied. The release kinetics of the drug was observed to fit best with korsmeyer peppas having regression coefficient of linear line as 0.999 and slope was 0.65. The bottles are loaded in accelerated stability chambers at 400C / 75 % RH conditions. Samples were analysed after one month and two months intervals.
[get full article]
