MICROWAVE SYNTHESIS, ANTICANCER EVALUATION TARGETING BREAST CANCER CELL LINES AND MOLECULAR DOCKING STUDIES USING AUTO DOC OF BENZOXAZOLE LINKED COMBRETASTATIN ANALOGUES

Trijoy Dutta and *Dr. Ayushi Chawla

Breast cancer remains a leading cause of cancer-related deaths globally, driving the need for more effective and selective therapeutic agents. Combretastatin A-4, a well-known natural stilbene, exhibits strong antimitotic activity by disrupting tubulin polymerization, yet its clinical use is limited due to poor solubility and structural instability. In this study, a novel series of benzoxazole-linked combretastatin analogue is designed and will be synthesized using microwave-assisted organic synthesis, a technique that offers advantages such as enhanced reaction rates, improved yields, and eco-friendly processing. The synthesized compounds are intended to be evaluated for their anticancer activity against breast cancer cell lines through in vitro cytotoxic assays. To complement experimental efforts, molecular docking studies will be conducted using AutoDock software to predict the binding affinity and interaction profiles of the analogues with cancer-related target proteins. The integration of synthetic chemistry, biological screening, and computational modelling is expected to contribute valuable insights into the structure–activity relationship of these hybrid molecules and support the development of potent candidates for breast cancer therapy.