mRNA-BASED THERAPEUTICS BEYOND VACCINES: APPLICATIONS IN ONCOLOGY

Saravanagiri A.*, M. Molungzang Aier, Adarsh S. Kumar, Debjit Bhakat, Anirban Debnath, Afrah Fathima, R. Roshinee, Dr. Gopal Kumar Sunilkumar Singh, Mehrosh Sirajoddin Patel and Dr. Darshan Bhuvaneshwari Bhushan Deshmukh

Messenger RNA (mRNA) therapeutics grabbed the world's attention during the COVID-19 pandemic vaccine development, but the potentials of mRNA vaccines go much beyond infectious diseases and into oncology. The review thus showcases how mRNA technology can revolutionize the field of cancer medicine as well. Applications include therapeutic cancer vaccines, mRNA encoding for immune-modulatory agents such as cytokines and monoclonal antibodies, and the modification of immune cells, such as CAR-T cells. Since mRNA can mount targeted and very powerful immune responses and also has a form of adaptability for personalized medicine, it truly presents mRNA as a suitable tool against a vast range of malignancies. The review further explores new delivery technologies, clinical evaluations, real-world applications, and the current hurdles of stability, delivery, and tumor heterogeneity. With more and more therapeutic mRNA advancing rapidly, oncology is witnessing the coming of a new wave that centers around precision, efficacy, and least system toxicity. Explore further and emphasizes the need for continued investigation and collaboration to harness the mRNA therapeutic potential in cancer therapeutics fully.