EXTRACTION, PHYTOCHEMICAL SCREENING AND ANTI‑ARTHRITIC POTENTIAL OF ANTIDESMA DIANDRUM EXTRACT
Anupam Gautam*, Sunil Shah, B. K. Dubey, Deepak Basedia
The present study was carried out to evaluate the extraction yield, phytochemical constituents, and anti-arthritic potential of the hydroalcoholic extract of Antidesma diandrum. The plant material was subjected to hydroalcoholic extraction, and the percentage yield was determined. Preliminary phytochemical screening of the extract revealed the presence of flavonoids, phenols, proteins, carbohydrates, and saponins. Quantitative analysis showed a total phenolic content of 0.263 mg gallic acid equivalent (GAE)/100 mg and a total flavonoid content of 0.742 mg quercetin equivalent (QE)/100 mg of extract. The anti-arthritic activity was evaluated using Freund’s adjuvant-induced arthritis model in rats. The hydroalcoholic extract was administered orally at doses of 100 mg/kg and 200 mg/kg and compared with aspirin (200 mg/kg) as a standard drug. The extract produced a significant, dose-dependent reduction in paw edema, particularly at the higher dose, which showed activity comparable to the standard drug. The observed anti-arthritic effect may be attributed to the presence of flavonoids and phenolic compounds with known anti-inflammatory properties. The results of the study scientifically support the traditional use of Antidesma diandrum in the management of inflammatory and arthritic conditions.
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